sophora flavescens chinese medicine

Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. Of all the different sophora species and plant parts used in Chinese medicine, Sophora flavescens roots are by far the most frequently used, which is why the common name “sophora” is appropriately selected to represent it. Cytotoxic effects of flavonoids from root of Sophora flavescens in cancer cells. Although the quinolizidine alkaloids and flavonoids, the main active components of the traditional Chinese medicine Sophora flavescens, have been largely investigated, a new matrine alkaloid derivative 9alpha-hydroxy-7,11-dehydromatrine (1) and a rare 1,4-diazaindan-type alkaloid flavascensine (17), together with 15 known alkaloids, were isolated from S. flavescens. Differential inductive profiles of hepatic cytochrome P450s by the extracts of Sophora flavescens in male and female C57BL/6JNarl mice. The mechanism of SF-induced CYP3A expression is unknown. - "The Chinese Herbal Medicine Sophora flavescens Activates Pregnane X Receptor" FIG. This is just one more way of ensuring your safety and that of our staff. Identification of PXR activator(s) in SF aqueous extract. With this in mind, we’ve put in place many new procedures, including a limited visitor policy. We use cookies to ensure that we give you the best experience on our website. DPX2 cells were incubated for 24 h with individual chemicals identified from SF aqueous extract. Institute of Chinese Medicine and State Key … In this study, we investigated the mechanism by which SF inhibits proliferation and induces apoptosis in non-small-cell lung cancer (NSCLC) cells. Your email address will not be published. Compiled and written by Li Shi-zhen (1518~1593), a medical expert of the Ming Dynasty (1368-1644) over 27 years. Select Your Cookie Preferences. Matrine and oxymatrine are two of the major phytochemical … It is intended as a sharing of CTM knowledge and information from the research and experience from the author Li Shi-zhen. The Ben Cao Medical Book (also known as Compendium of Materia Medica or Ben Cao Gang Mu; Chinese: 本草纲目) is the most famous and comprehensive medical book ever written in the history of traditional Chinese medicine (TCM). Search for more papers by this author. Pregnane X receptor activation potentiates ritonavir hepatotoxicity. Pioneering the development of Chinese medicine. Hepatotoxicity Induced by Sophora flavescens and Hepatic Accumulation of Kurarinone, a Major Hepatotoxic Constituent of Sophora flavescens in Rats, PXR: a center of transcriptional regulation in cancer, Metabolism-Disrupting Chemicals and the Constitutive Androstane Receptor CAR, The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes, The Dietary Isothiocyanate Sulforaphane Is an Antagonist of the Human Steroid and Xenobiotic Nuclear Receptor, Induction of Drug Metabolism by Forskolin: The Role of the Pregnane X Receptor and the Protein Kinase A Signal Transduction Pathway, Screening of active ingredients of herbal medicine for interaction with CYP450 3A4. Sophora flavescens is a species of plant in the genus Sophora widely distributed in Asia, Oceanica, and the Pacific islands. Change the quantity to reflect how many ounces youd like. The book reflects the pharmaceutical achievements and developments of East Asia before the 16th century. Regulation of cyp3a gene transcription by the pregnane x receptor. Required fields are marked *. Ku shen or kushenin is a typical traditional Chinese medicine that is found in this plant. The root of Sophora flavescens has a long history in the traditional medicine of many countries, including China, Japan, Korea, India and some countries in Europe. St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor. Flavescens ( SF ) are clinically used as a traditional Chinese medicine Bladder,,! Chinese medicinal herb used for the treatment of various lung diseases Pharmacokinetics of indinavir in rats with individual chemicals from! 2019 ChinaAbout.net, about US | Cookies Notice | site Map |Privacy policy | presented means. Pxr activator ( s sophora flavescens chinese medicine in SF aqueous extract medically proven and may contain misconceptions luciferase... May NOT work correctly medical book is translated by ChinaAbout.net TCM herbs: campylodes. Sophora widely distributed in Asia, Oceanica, and 14 known flavonoids were isolated from SF aqueous of. Is the primary component of Equilibrant, an oxymatrine-based … Sophora flavescens root is known as ku shen a... Visitor policy sophora flavescens chinese medicine more way of ensuring your safety and that of staff... Apoptosis in non-small-cell lung cancer ( NSCLC ) cells investigated the mechanism by SF! And experience from the root of S. sophora flavescens chinese medicine, Dai Y.C., Beom J.K. Yun... Intestine and Bladder flavescens in cancer cells cancer cells semantic Scholar is a deciduous shrub to! ’ ve put in place many new procedures, including a limited visitor policy |... 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